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University of Essex converts 672 antibodies into intrabodies that target neurodegenerative disease proteins
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University of Essex researchers used AI to convert 672 antibodies into intrabodies that remain stable inside cells, potentially enabling new treatments for Alzheimer's, Parkinson's, and motor neurone disease.
This method addresses a key challenge in antibody therapy: antibodies normally cannot function inside cells. By engineering intrabodies that are stable in the intracellular environment, researchers can now target disease-causing proteins where they act. The free availability of these molecules could accelerate research into neurodegenerative diseases.
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Electrical charge determines whether antibody fragments can remain stable and functional inside cells.
The team used AI-powered protein redesign to convert 672 antibodies into intrabodies targeting disease-related proteins.
The redesigned intrabodies will be made freely available to other scientists following publication.
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